Hemangioma-thrombocytopenia syndrome associated with microangiopathic hemolytic anemia.

hocytopenia associated with a large hemangiorna of the right arm and axilla. Initial treatment of the hemangioma with x-irradiation was followed by regression of the hemangioma. \Vhen a severe relal)se occurred, investigation of this patiei1t revealed a markedly diminished pl ttelet survival time and absence of a platelet agglutinin or complement-fixing antibody. Increased radioactivity over the hemangioma as well as over the liver and spleen following the infusion of radiochromatetagged platelets suggested sequestration. A combination of reticulocytosis and helmet cells was observed, possibly indicating an associated microangiopathic hemolytic anemia. Such abnormalities have not been previously described in this synclroi’ne and their description in this report has led us to propose possible hypotheses for the pathogenesis of this syndrome, which may he called “microangiopathic thrombocytopenic purpura (MTP).”